2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W009216S
    2'-Deoxycytidine-5'-monophosphoric acid-15N3 98.76%
    2'-Deoxycytidine-5'-monophosphoric acid-15N3 is the 15N labeled 2'-Deoxycytidine-5'-monophosphoric acid. 2'-Deoxycytidine-5'-monophosphoric acid is an endogenous metabolite.
    2'-Deoxycytidine-5'-monophosphoric acid-15N3
  • HY-W009371A
    D-Ribose 5-phosphate 4300-28-1 98%
    D-Ribose 5-phosphate is an intermediate of the oxidative branch of the pentose phosphate pathway (PPP) and an end product of the nonoxidative branch of the PPP. D-Ribose 5-phosphate is used in the synthesis of nucleotides and nucleic acids.
    D-Ribose 5-phosphate
  • HY-W009417R
    Cedryl acetate (Standard) 77-54-3
    Cedryl acetate (Standard) is the analytical standard of Cedryl acetate. This product is intended for research and analytical applications. Cedryl acetate is a tricyclic sesquiterpene isolated from the plant Cunninghamia lanceolata. Cedryl acetate shows α-glucosidase inhibitory activity[1].
    Cedryl acetate (Standard)
  • HY-W009516R
    Dibenzyl disulfide (Standard) 150-60-7
    Dibenzyl disulfide (Standard) is the analytical standard of Dibenzyl disulfide. This product is intended for research and analytical applications. Dibenzyl disulfide is an endogenous metabolite.
    Dibenzyl disulfide (Standard)
  • HY-W009731R
    Dibenzoylmethane (Standard) 120-46-7
    Dibenzoylmethane (Standard) is the analytical standard of Dibenzoylmethane. This product is intended for research and analytical applications. Dibenzoylmethane, a minor ingredient in licorice, activates Nrf2 and prevents various cancers and oxidative damage. Dibenzoylmethane, an analog of curcumin, results in dissociation from Keap1 and nuclear translocation of Nrf2.
    Dibenzoylmethane (Standard)
  • HY-W010042S
    L-Glucose-13C 478519-02-7 ≥98.0%
    L-Glucose-13C is the 13C labeled L-Glucose. L-Glucose (L-(-)-Glucose) is an enantiomer of D-glucose. L-Glucose can promote food intake.
    L-Glucose-13C
  • HY-W010066R
    4-(1,2-Dihydroxyethyl)benzene-1,2-diol (Standard) 28822-73-3
    Scopolamine (hydrobromide trihydrate) (Standard) is the analytical standard of Scopolamine (hydrobromide trihydrate). This product is intended for research and analytical applications. Scopolamine hydrobromide trihydrate (Hyoscine hydrobromide trihydrate) is used in ophthalmic preparations and has the potential for transdermal patches of motion sickness.
    4-(1,2-Dihydroxyethyl)benzene-1,2-diol (Standard)
  • HY-W010255S
    Phenylglyoxylic acid-d5 1217089-53-6 98%
    Phenylglyoxylic acid-d5 (Benzoylformic acid-d5) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human.
    Phenylglyoxylic acid-d5
  • HY-W010270A
    Aurothiomalate disodium 74916-57-7 98%
    Aurothiomalate (disodium) is a TRPA1 inhibitor. Aurothiomalate (disodium) inhibits NF-κB activation and iNOS expression. Aurothiomalate (disodium) promotes M2 transformation of macrophages and increases the expression of TREM-2 and arginase-1. Aurothiomalate (disodium) can be used in the study of liver fibrosis/cirrhosis and arthritis.
    Aurothiomalate disodium
  • HY-W010381S
    2-Methylsuccinic acid-d6 347840-08-8 98%
    2-Methylsuccinic acid-d6 is the deuterium labeled 2-Methylsuccinic acid. 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy.
    2-Methylsuccinic acid-d6
  • HY-W010435R
    Sulcatone (Standard) 110-93-0
    Sulcatone (Standard) (6-Methyl-5-hepten-2-one (Standard)) is the analytical standard of Sulcatone (HY-W010435). This product is intended for research and analytical applications. Sulcatone (6-Methyl-5-hepten-2-one) is a plant-derived volatile organic compound with activities such as insecticidal, antifungal, and blood pressure-lowering effects. Sulcatone also serves as an insect pheromone and an endogenous metabolite, which can be found in feces. Changes in Sulcatone levels can be used for the auxiliary diagnosis of ulcerative colitis.
    Sulcatone (Standard)
  • HY-W010450S
    Thymine-d4 200496-79-3 98%
    Thymine-d4 is the deuterium labeled Thymine. Thymine is one of the four nucleobases in the nucleic acid of DNA and can be a target for actions of 5-fluorouracil (5-FU) in cancer treatment, with a Km of 2.3 μM.
    Thymine-d4
  • HY-W010452S
    3-Hydroxybutyric acid-d2 sodium 352439-00-0 98%
    3-Hydroxybutyric acid-d2 (sodium) is the deuterium labeled 3-Hydroxybutyric acid sodium. 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids.
    3-Hydroxybutyric acid-d2 sodium
  • HY-W010476R
    2,3,5-Trimethylpyrazine (Standard) 14667-55-1
    2,3,5-Trimethylpyrazine (Standard) is the analytical standard of 2,3,5-Trimethylpyrazine. This product is intended for research and analytical applications. 2,3,5-Trimethylpyrazine is an endogenous metabolite.
    2,3,5-Trimethylpyrazine (Standard)
  • HY-W010476S
    2,3,5-Trimethylpyrazine-d9 85735-49-5 98%
    2,3,5-Trimethylpyrazine-d9 is the deuterium labeled 2,3,5-Trimethylpyrazine. 2,3,5-Trimethylpyrazine is an endogenous metabolite.
    2,3,5-Trimethylpyrazine-d9
  • HY-W010516R
    2-Methylvaleric acid (Standard) 97-61-0
    2-Methylvaleric acid (Standard) is the analytical standard of 2-Methylvaleric acid. This product is intended for research and analytical applications. 2-Methylvaleric acid is a branched short-chain fatty acid (SCFA) produced by the metabolism of branched-chain amino acids by gut microbes. 2-Methylvaleric acid can be used as a potential biomarker for metabolic diseases such as type 2 diabetes, and its content is significantly reduced in the feces of diabetic mice. 2-Methylvaleric acid may regulate host energy metabolism and inflammatory response through G protein-coupled receptors (GPCRs) or histone deacetylase (HDAC) inhibition. 2-Methylvaleric acid can be used to study gut microbe-host interactions and metabolic diseases as a fecal biomarker[1][2].
    2-Methylvaleric acid (Standard)
  • HY-W010589R
    H-Abu-OH (Standard) 1492-24-6
    H-Abu-OH (Standard) is the analytical standard of H-Abu-OH. This product is intended for research and analytical applications. H-Abu-OH, one of the three isomers of aminobutyric acid, is elevated in the plasma of children with with Reye's syndrome, tyrosinemia, homocystinuria, nonketotic hyperglycinemia, and ornithine transcarbamylase deficiency.
    H-Abu-OH (Standard)
  • HY-W010649R
    Isoxazole (Standard) 288-14-2
    Amfenac (Sodium Hydrate) (Standard) is the analytical standard of Amfenac (Sodium Hydrate). This product is intended for research and analytical applications. Amfenac Sodium Hydrate is a COX-2 inhibitor.
    Isoxazole (Standard)
  • HY-W010735R
    ATP disodium salt hydrate (Standard) 34369-07-8
    ATP (disodium salt hydrate) (Standard) is the analytical standard of ATP (disodium salt hydrate). This product is intended for research and analytical applications. ATP disodium salt hydrate (Adenosine 5'-triphosphatedisodium salt hydrate) is a central component of energy storage and metabolism in vivo, provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP disodium salt hydrate is an important endogenous signaling molecule in immunity and inflammation.
    ATP disodium salt hydrate (Standard)
  • HY-W010736S
    1,2-Dipalmitoyl-sn-glycerol-d9 1872379-48-0 98%
    1,2-Dipalmitoyl-sn-glycerol-d9 is a deuterated labeled 1,2-Dipalmitoyl-sn-glycerol. 1,2-Dipalmitoyl-sn-glycerol is an endogenous metabolite.
    1,2-Dipalmitoyl-sn-glycerol-d9
Cat. No. Product Name / Synonyms Application Reactivity